Ipratropium Impurity E

Ipratropium Impurity E - Names and Identifiers

Name	endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate
Synonyms	Ipratropium Impurity E N-Isopropylnoratropine N-DesMethyl IpratropiuM Ipratropium Bromide Impurity 13(Ipratropium EP Impurity E) endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl (hydroxymethyl)phenylacetate α-(HydroxyMethyl)benzeneacetic Acid endo-8-(1-Methylethyl)-8- azabicyclo[3.2.1]oct-3-yl Ester α-(HydroxyMethyl)benzeneacetic Acid endo-8-(1-Methylethyl)-8- azabicyclo[3.2.1]oct-3-yl Ester α-(HydroxyMethyl)benzeneacetic Acid (3-Endo)-8-(1-Methylethyl)-8-azabicyclo[3.2.1]- oct-3-yl Ester α-(HydroxyMethyl)benzeneacetic Acid (3-Endo)-8-(1-Methylethyl)-8-azabicyclo[3.2.1]- oct-3-yl Ester rac-(R*)-α-(Hydroxymethyl)benzeneacetic acid (1R,5S)-8-isopropyl-8-azabicyclo[3.2.1]octane-3α-yl ester
CAS	22235-81-0
EINECS	2448591

Ipratropium Impurity E - Physico-chemical Properties

Molecular Formula	C19H27NO3
Molar Mass	317.42258
Density	1.15±0.1 g/cm3(Predicted)
Melting Point	112-114°C
Boling Point	448.8±45.0 °C(Predicted)
Solubility	Chloroform (Slightly), Methanol (Slightly)
Appearance	Solid
Color	White to Pale Orange
pKa	14.12±0.10(Predicted)
Storage Condition	Refrigerator

Ipratropium Impurity E - Upstream Downstream Industry

Raw Materials

Noratropine
endo-8-isopropyl-8-azabicyclo[3.2.1]octan-3-ol
Acetyltropylic chloride
Ethyl phenylacetate
Atropine
Acetone

Ipratropium Impurity E - Introduction

endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl is an organic compound with the chemical name endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl.

Nature:
endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl is a white crystalline solid, insoluble in water at room temperature, soluble in some organic solvents such as ethanol and Ether solvents. Its structure contains eight-membered heterocyclic ring, in which the nitrogen atom and the hydroxy methyl group on the benzene ring make it have special chemical properties.

Use:
endo-(±)-8-aza-8-isopropylbicyclo[3.2.1]oct-3-yl is mainly used in the field of drug research and manufacturing. It is an impurity of the peripheral anticholinergic drug ipratropium bromide. It is used to detect the purity and quality of ipratropium bromide products and perform quality control.

Method:
endo-(±)-8-aza-8-isopropylbicyclo[3.2.1] The preparation method of oct-3-yl (hydroxymethyl)phenylacetate is generally realized by organic synthetic chemical reaction. Specific methods include the synthesis of intermediate compounds followed by specific reaction steps to give the final product.

Safety Information:

Last Update：2024-04-09 02:00:51